A retrospective look at developments in size exclusion chromatography from the early Hamielec research era to the present day

At the start of Archie Hamielec's research career, size exclusion chromatography (SEC) (including gel permeation [GPC]) was in its infancy as an analytical and preparative laboratory technique polymer science engineering. As described below, Hamielec saw potential early his academic career among group pioneers who took it from a developing to what is now. His group's work instrumental improving understanding mechanism separation SEC setting up best procedures for sample handling. In addition, much done assess detectors improve data collection obtain consistent/reliable measurements. Importantly, he established key method obtaining molecular information support reaction Nowadays we take granted that can use weight rapidly reliably with user-friendly computer-aided analyses. This ease routine practicality stems base researchers built. Although now well-developed (almost ‘black box’) there are still areas novel interest into analysis complex samples. has led modern developments forging ahead expanding applicability exploitation multi-detector systems detectors.